Hofmann, Matthias; Pflanzer, Ralph; Habib, Anowarul; Shelke, Amit; Bereiter-Hahn, Jürgen; Bernd, August; Kaufmann, Roland; Sader, Robert; Kippenberger, Stefan (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-04-22)
Elevated tumor interstitial fluid pressure (TIFP) is a prominent feature of solid tumors and hampers the
transmigration of therapeutic macromolecules, for example, large monoclonal antibodies, from tumor-supplying
vessels into the tumor interstitium. TIFP values of up to 40 mm Hg have been measured in experimental solid
tumors using two conventional invasive techniques: the wick-in-needle and the ...